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Calprotectin in rheumatic diseases: a review
Magdalena Kopeć-Mędrek1, Małgorzata Widuchowska1, Eugeniusz J Kucharz1
1Department of Internal Medicine and Rheumatology, Katowice, Poland.
Reumatologia
|January 25, 2017
Summary
Calprotectin (MRP8/14) shows promise as a sensitive biomarker for rheumatoid disease activity. This review examines its concentration in various rheumatic conditions, suggesting it may outperform traditional inflammatory markers.
Area of Science:
- Biochemistry and Molecular Biology
- Rheumatology and Immunology
Background:
- Calprotectin, a heterodimeric complex of S100A8/A9 (MRP8/14), is composed of myeloid-related protein 8 and MRP-14.
- It is increasingly recognized for its role in inflammatory processes.
Purpose of the Study:
- To review the current literature on calprotectin concentrations in patients with various rheumatic diseases.
- To evaluate calprotectin as a potential biomarker for disease activity in rheumatology.
Main Methods:
- Literature review of studies reporting calprotectin levels in patients with rheumatic diseases.
- Analysis of calprotectin concentrations in conditions including rheumatoid arthritis, juvenile idiopathic arthritis, and systemic lupus erythematosus.
Main Results:
- Calprotectin (MRP8/14) is considered a potentially more sensitive biomarker of disease activity in rheumatoid disease.
- Its sensitivity may exceed that of conventional inflammatory indices like ESR and CRP.
Conclusions:
- Calprotectin demonstrates potential as a valuable biomarker for assessing disease activity across a spectrum of rheumatic conditions.
- Further research can elucidate its clinical utility in managing rheumatoid diseases.
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