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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Multiple autoimmune syndrome with celiac disease.

Singh Harpreet1, Jain Deepak1, B Kiran1

  • 1Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak (Haryana), India.

Reumatologia
|January 25, 2017
PubMed
Summary

Multiple autoimmune syndrome (MAS) involves multiple autoimmune disorders in one person. This case highlights four conditions in a single patient, emphasizing the need for ongoing monitoring in those at risk.

Keywords:
Sjögren’s syndromeceliac diseasemultiple autoimmune syndromesystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Multiple autoimmune syndrome (MAS) is defined as the presence of three or more distinct autoimmune disorders within a single individual.
  • Familial, immunologic, and infectious factors are recognized as potential contributors to the pathogenesis of MAS.
  • Individuals with a single autoimmune disorder have a significantly increased risk (25%) of developing additional autoimmune conditions.

Purpose of the Study:

  • To report a rare case of multiple autoimmune syndrome type 3 with celiac disease.
  • To underscore the importance of vigilant surveillance for new autoimmune disease development in predisposed patients.

Main Methods:

  • Case report of a 32-year-old female patient.
  • Detailed clinical evaluation and diagnosis of co-existing autoimmune disorders.

Main Results:

  • The patient was diagnosed with four autoimmune diseases: autoimmune hypothyroidism, Sjögren's syndrome, systemic lupus erythematosus (SLE), and celiac disease.
  • This constellation of diseases led to the diagnosis of multiple autoimmune syndrome type 3 with celiac disease.

Conclusions:

  • This case illustrates a complex presentation of MAS, involving four distinct autoimmune conditions.
  • Clinicians should maintain a high index of suspicion and conduct continuous surveillance for the emergence of new autoimmune diseases in patients with established autoimmune disorders.