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Prognostic role of copeptin with all-cause mortality after heart failure: a systematic review and meta-analysis

Peng Zhang1, Xiaomei Wu1, Guangxiao Li1

  • 1Department of Clinical Epidemiology, Center of Evidence-Based Medicine, Institute of Cardiovascular Disease, The First Hospital of China Medical University, Shenyang, People's Republic of China.

Therapeutics and Clinical Risk Management
|January 25, 2017
PubMed

Insights

Elevated copeptin levels in heart failure (HF) patients are linked to a higher risk of all-cause mortality. This meta-analysis confirms copeptin as a valuable prognostic biomarker for HF.

Area of Science:

  • Cardiology
  • Biomarkers
  • Prognostics

Background:

  • Copeptin, a vasopressin precursor fragment, is a potential prognostic biomarker in heart failure (HF).
  • Previous studies suggest a link between copeptin levels and HF outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of plasma copeptin levels for all-cause mortality in patients with heart failure (HF).

Main Methods:

  • A meta-analysis of 17 prospective studies involving 5,989 participants.
  • Pooled hazard ratios (HRs) and standardized mean differences (SMDs) were calculated.
  • Subgroup and sensitivity analyses were conducted to assess heterogeneity.

Main Results:

  • Higher circulating copeptin levels were significantly associated with an increased risk of all-cause mortality in HF patients.
  • Copeptin levels were significantly higher in HF patients who died compared to survivors (SMD = 1.19).
  • Results remained stable across sensitivity and subgroup analyses.

Conclusions:

  • Circulating copeptin is a novel and valuable biomarker for predicting all-cause mortality in patients with heart failure (HF).
  • Copeptin may improve risk stratification and patient management in HF.
Abstract

Keywords:
all-cause mortalitycopeptinheart failuremeta-analysis

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