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Hypercalcemia due to Primary Hepatic Lymphoma
Andrew Hsu1, Michael Gagnier1, Elizabeth Ryer1
1Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Case Reports in Hematology
|January 25, 2017
Summary
A persistent hypercalcemia case was investigated. Primary hepatic lymphoma was identified as the unexpected cause, despite treatment adjustments for osteoporosis.
Area of Science:
- Oncology
- Endocrinology
- Rheumatology
Background:
- Mixed connective tissue disease and pulmonary fibrosis management often involves immunosuppressants.
- Osteoporosis is a common comorbidity, frequently treated with bone-anabolic agents like teriparatide.
Observation:
- A 65-year-old female presented with persistent hypercalcemia.
- Hypercalcemia symptoms continued even after teriparatide discontinuation.
Findings:
- Primary hepatic lymphoma was diagnosed as the underlying cause of hypercalcemia.
- Malignancy-associated hypercalcemia can occur in hepatic lymphoma.
Implications:
- Highlights the importance of considering rare causes of hypercalcemia in patients with autoimmune diseases.
- Underscores the need for thorough diagnostic workups when hypercalcemia is refractory to standard treatments.
- Emphasizes the potential for hepatic lymphoma to manifest with hypercalcemia.
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