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Accuracy of Cardiac Output by Nine Different Pulse Contour Algorithms in Cardiac Surgery Patients: A Comparison with
Ole Broch1, Berthold Bein2, Matthias Gruenewald1
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schleswig-Holstein, Germany.
Insights
Nine cardiac output (CO) algorithms showed poor accuracy compared to transpulmonary thermodilution before and after cardiopulmonary bypass. The Liljestrand-Zander algorithm demonstrated the highest reliability for CO estimation.
Area of Science:
- Cardiovascular Physiology
- Medical Devices
- Surgical Innovation
Background:
- Cardiac output (CO) monitoring is crucial in critical care and surgery.
- Various pulse contour analysis algorithms exist for non-invasive CO estimation.
- Transpulmonary thermodilution is a reference standard for CO measurement.
Purpose of the Study:
- To compare the accuracy of nine pulse contour algorithms against transpulmonary thermodilution.
- To evaluate CO estimation before and after cardiopulmonary bypass (CPB).
- To assess the trending capability of algorithms during hemodynamic changes.
Main Methods:
- Thirty patients undergoing coronary surgery were studied.
- CO measured by transpulmonary thermodilution (CO_TPTD) and nine pulse contour algorithms (CO_X1-9).
- Algorithms calibrated using esophageal Doppler; passive leg raising maneuver performed.
Main Results:
- Poor correlation and high percentage error (>30%) between pulse contour algorithms and CO_TPTD.
- Most algorithms exhibited insufficient trending ability before and after CPB.
- The Liljestrand-Zander algorithm showed the best reliability among tested methods.
Conclusions:
- Nine pulse contour algorithms demonstrated inadequate accuracy for CO estimation compared to transpulmonary thermodilution.
- Less-invasive algorithms had insufficient capability for trending hemodynamic changes post-CPB.
- The Liljestrand-Zander algorithm is the most reliable among the evaluated pulse contour methods.
Abstract:
Objective. Today, there exist several different pulse contour algorithms for calculation of cardiac output (CO). The aim of the present study was to compare the accuracy of nine different pulse contour algorithms with transpulmonary thermodilution before and after cardiopulmonary bypass (CPB). Methods. Thirty patients scheduled for elective coronary surgery were studied before and after CPB. A passive leg raising maneuver was also performed. Measurements included CO obtained by transpulmonary thermodilution (COTPTD) and by nine pulse contour algorithms (COX1-9). Calibration of pulse contour algorithms was performed by esophageal Doppler ultrasound after induction of anesthesia and 15 min after CPB. Correlations, Bland-Altman analysis, four-quadrant, and polar analysis were also calculated. Results. There was only a poor correlation between COTPTD and COX1-9 during passive leg raising and in the period before and after CPB. Percentage error exceeded the required 30% limit. Four-quadrant and polar analysis revealed poor trending ability for most algorithms before and after CPB. The Liljestrand-Zander algorithm revealed the best reliability. Conclusions. Estimation of CO by nine different pulse contour algorithms revealed poor accuracy compared with transpulmonary thermodilution. Furthermore, the less-invasive algorithms showed an insufficient capability for trending hemodynamic changes before and after CPB. The Liljestrand-Zander algorithm demonstrated the highest reliability. This trial is registered with NCT02438228 (ClinicalTrials.gov).
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