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Updated: Mar 8, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Vascular Reactivity of Isolated Aorta to Study the Angiotensin-(1-7) Actions
Roberto Q Lautner1,2, Rodrigo A Fraga-Silva1,3, Anderson J Ferreira1,4
1National Institute of Science and Technology in Nanobiopharmaceutics, Gerais, Brazil.
Abstract:
Since the early 1950s, vascular reactivity using isolated vessel rings has been a useful and efficient model for physiological and pharmacological studies. This experimental model was utilized in the milestone study of Dr. Robert Furchgott to discover the endothelium-derived relaxation factor (EDRF) nitric oxide (NO), opening new avenues and scientific perspectives in the vascular pathophysiology. Moreover, the isolated vessel ring preparation had an important contribution to understand many vasoactive systems. Here, we described the isolated aorta technique and pitfalls about the use of angiotensin-(1-7) peptide in this preparation.
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