Primary cutaneous diffuse large B-cell lymphoma presenting as chronic non-healing ulcer

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is a rare and aggressive hematologic malignancy.
• PCDLBCL typically presents with skin lesions but can have varied clinical presentations.

Observation:

• A 91-year-old female presented with an unusual manifestation of PCDLBCL.
• The presentation mimicked common conditions such as chronic non-healing venous ulceration.

Findings:

• Dermatopathologic evaluation was essential in establishing the correct diagnosis.
• This case highlights a rare presentation of PCDLBCL.

Implications:

• Clinicians should consider PCDLBCL in the differential diagnosis of chronic non-healing leg ulcers.
• Timely diagnosis prevents misdiagnosis and delays in appropriate patient management.
• Awareness of rare presentations improves patient outcomes for aggressive lymphomas.