Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata
Wei-Yan Qi1, Yu Shen2, Yan Wu2
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
Twelve cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata. Their structures were elucidated on the basis of spectroscopic data. Five of these compounds displayed moderate inhibitory activity against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 20-Oxygenated cembranes are rare.
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