Critical review: CPAP and weight management of obstructive sleep apnea cardiovascular co-morbidities

The cardiovascular co-morbidities of obstructive sleep apnea (OSA) are similar to those of obesity. Cardiovascular co-morbidities often are the cause of adverse outcomes in overweight/obese OSA patients. Continuous positive airway pressure (CPAP) therapy resolves the symptoms of OSA, but may, or may not lead to improvement of a given cardiovascular co-morbidity. The impact of CPAP on cardiovascular risk variables, adverse cardiovascular events in overweight/obese OSA patients has been evaluated primarily in prospective, uncontrolled cohort studies. These studies show improvement in myocardial and endothelial function, blood pressure, left ventricular performance and stroke survival. Randomized controlled studies (RCTs) examining the effect of weight management on cardiovascular risk factors and disease outcomes show that intentional weight loss leads to improvement in cardiovascular risk, hypertension, coronary artery disease, but not in stroke. Weight loss improves mortality in relatively healthy overweight/obese populations, but possibly not in all groups with cardiometabolic diseases. Clinicians caring for overweight/obese OSA patients should consider the advantages of incorporating weight management into their treatment programs for such patients.