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Downhill exercise training in monocrotaline-injected rats: Effects on echocardiographic and haemodynamic variables
Irina Enache1, Fabrice Favret2, Stéphane Doutreleau1
1Service de physiologie et d'explorations fonctionnelles, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 67091 Strasbourg, France; Équipe d'accueil 3072, fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67000 Strasbourg, France.
Background:
Eccentric exercise training has been shown to improve muscle force strength without excessive cardiovascular stress. Such an exercise modality deserves to be tested in pulmonary arterial hypertension.
Aim:
We aimed to assess the effects of an eccentric training modality on cardiac function and survival in an experimental monocrotaline-induced model of pulmonary arterial hypertension with right ventricular dysfunction.
Methods:
Forty rats were randomly assigned to one of four groups: 40mg/kg monocrotaline-injected sedentary rats; 40mg/kg monocrotaline-injected eccentric-trained rats; sedentary control rats; or eccentric-trained control rats. Eccentric exercise training consisted of downhill running on a treadmill with a -15° slope for 30minutes, 5 days a week for 4 weeks. Training tolerance was assessed by echocardiography, right ventricle catheterization and the rats' maximal eccentric speed.
Results:
Survival in monocrotaline-injected eccentric-trained rats was not different from that in monocrotaline-injected sedentary rats. Monocrotaline-injected eccentric-trained rats tolerated this training modality well, and haemodynamic status did not deteriorate further compared with monocrotaline-injected sedentary rats. The eccentric maximal speed decline was less pronounced in trained compared with sedentary pulmonary arterial hypertension rats.
Conclusions:
Eccentric exercise training had no detrimental effects on right heart pressure, cardiac function and survival in rats with stable monocrotaline-induced pulmonary hypertension.
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