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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Thyroid Stimulating Hormone Receptor

Murat Tuncel1

  • 1Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey, Phone: +90 536 213 03 41,

Molecular Imaging and Radionuclide Therapy
|January 25, 2017
PubMed

Insights

Thyroid stimulating hormone receptor (TSHR) is key to thyroid hormone metabolism and cell function. While not directly causing cancer, TSHR mutations are linked to thyroid diseases like hyperthyroidism and influence tumor growth.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • The thyroid stimulating hormone receptor (TSHR) is essential for regulating thyroid hormone production and thyroid cell proliferation.
  • Dysregulation of TSHR function is implicated in various endocrine disorders.
  • TSHR's role extends beyond hormone regulation to influencing thyroid cell growth and potentially tumor development.

Purpose of the Study:

  • To provide a comprehensive review of the thyroid stimulating hormone receptor (TSHR).
  • To elucidate the role of TSHR in thyroid hormone metabolism and cell function.
  • To discuss the association between TSHR alterations and thyroid diseases, including hyperthyroidism and cancer growth.

Main Methods:

  • Literature review of scientific articles on TSHR.
  • Analysis of genetic and epigenetic factors affecting TSHR.
  • Review of clinical data linking TSHR to thyroid pathologies.

Main Results:

  • TSHR is a critical regulator of thyroid hormone metabolism and thyroid cell growth.
  • Mutations in TSHR are a primary cause of hyperthyroidism.
  • While not a direct carcinogen, TSHR plays a significant role in the growth of thyroid tumors initiated by oncogenes.

Conclusions:

  • TSHR is a central player in thyroid physiology and pathophysiology.
  • Understanding TSHR is crucial for diagnosing and managing thyroid diseases.
  • Further research into TSHR's role in tumorigenesis may offer new therapeutic targets.

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