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Updated: Mar 8, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window
Qinglai Yang1,2, Zhuoran Ma3, Huasen Wang1
1Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, China.
Abstract:
A new design for second near-infrared window (NIR-II) molecular fluorophores based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structure is reported. With 3,4-ethylenedioxy thiophene as the donor and fluorene as the shielding unit, the best performance fluorophores IR-FE and IR-FEP exhibit an emission quantum yield of 31% in toluene and 2.0% in water, respectively, representing the brightest organic dyes in NIR-II region reported so far.
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