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Updated: Mar 8, 2026

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

21.5K

Murine Full-thickness Skin Transplantation.

Chih-Hsien Cheng1, Chen-Fang Lee2, Madeline Fryer3

  • 1Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Department of Liver and Transplantation Surgery, Chang-Gung Transplantation Institute, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine; chengcchj@gmail.com.

Journal of Visualized Experiments : Jove
|January 25, 2017
PubMed
Summary

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This study details a reproducible murine full-thickness skin transplantation protocol. It

Area of Science:

  • Immunology
  • Surgical Research

Background:

  • Murine full-thickness skin transplantation is a standard in vivo model.
  • It is widely used for studying alloimmune responses and graft rejection.
  • The model offers reproducibility and ease of monitoring graft rejection.

Purpose of the Study:

  • To present a detailed protocol for murine full-thickness skin transplantation.
  • To outline critical steps for successful skin graft procedures in mice.
  • To facilitate research in transplantation immunology and tolerance assessment.

Main Methods:

  • Detailed description of the full-thickness skin transplantation procedure in mice.
  • Emphasis on critical steps for graft preparation and placement.
  • Guidance on monitoring graft take and rejection.

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Murine Skin Transplantation
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Related Experiment Videos

Last Updated: Mar 8, 2026

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

21.5K
Murine Skin Transplantation
06:42

Murine Skin Transplantation

Published on: January 16, 2008

24.0K
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

11.0K

Main Results:

  • The protocol ensures a reproducible alloimmune response and graft rejection.
  • Low complication rates are associated with the procedure.
  • Common causes of graft failure are identified as technical errors.

Conclusions:

  • Murine skin transplantation is an accessible and reliable model for transplantation research.
  • The presented protocol aims to improve success rates and reproducibility.
  • This model is valuable for assessing donor-specific tolerance.