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Related Experiment Video

Updated: Mar 8, 2026

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
09:34

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation

Published on: October 31, 2025

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Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation.

J M Diamond1, E Cantu2, M K Porteous1

  • 1Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 25, 2017
PubMed
Summary
This summary is machine-generated.

Gene expression in peripheral blood differs in lung transplant recipients with primary graft dysfunction (PGD). These immune gene expression changes occur early after transplant and may impact allograft survival.

Keywords:
genomicslung failure/injurylung transplantation/pulmonologymolecular biology: mRNA/mRNA expressiontranslational research/science

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Area of Science:

  • Immunology
  • Transplantation Biology
  • Genomics

Background:

  • Primary graft dysfunction (PGD) is a significant complication following lung transplantation.
  • Recipient immune responses to the allograft are critical for transplant success.
  • Understanding early molecular events in PGD is crucial for improving outcomes.

Purpose of the Study:

  • To investigate longitudinal differences in peripheral blood gene expression in lung transplant recipients with and without PGD.
  • To identify specific genes and pathways associated with PGD development.
  • To determine the temporal dynamics of gene expression changes related to PGD.

Main Methods:

  • Peripheral blood RNA expression was measured in 106 lung transplant recipients over the first post-transplant year.
  • A panel of 100 hypothesis-driven genes was analyzed.
  • PGD was defined as grade 3 within 72 hours post-transplant.

Main Results:

  • Eighteen genes showed differential expression over the first year in relation to PGD.
  • Sixteen genes, primarily related to innate immunity and inflammasome pathways, were overexpressed within 7 days in PGD patients.
  • Thirteen genes, including T cell and adaptive immune regulation genes, were underexpressed within 7 days in PGD patients.
  • Gene expression differences were detectable as early as 2 hours post-reperfusion.

Conclusions:

  • Peripheral blood gene expression profiles, particularly involving innate and adaptive immunity, are altered in lung transplant recipients experiencing PGD.
  • These molecular signatures emerge very early after transplantation, within hours of reperfusion.
  • Further research is warranted to explore the long-term prognostic value of these early gene expression changes for allograft fate.