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Related Experiment Video

Updated: Mar 8, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

704

Copeptin Predicts Mortality in Critically Ill Patients.

Konstantin A Krychtiuk1,2, Maria C Honeder1, Max Lenz1

  • 1Department of Internal Medicine II-Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Plos One
|January 25, 2017
PubMed
Summary

High copeptin levels at intensive care unit (ICU) admission indicate increased 30-day mortality risk in critically ill patients. This stress biomarker is particularly predictive in medical ICU admissions, independent of other factors.

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Last Updated: Mar 8, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

704

Area of Science:

  • Critical Care Medicine
  • Biomarkers
  • Endocrinology

Background:

  • Critically ill patients in medical ICUs have high mortality rates.
  • Vasopressin acts as a stress hormone, and copeptin mirrors its levels.
  • Copeptin is a reliable biomarker for stress and has been linked to outcomes in various conditions.

Purpose of the Study:

  • To investigate the association between circulating copeptin levels upon ICU admission and 30-day mortality.
  • To determine if copeptin can serve as a predictive biomarker for mortality in critically ill patients.

Main Methods:

  • A single-center prospective observational study.
  • Included 225 consecutive patients admitted to a tertiary medical ICU.
  • Measured copeptin levels at ICU admission using an automated sandwich immunofluorescent assay.

Main Results:

  • Median copeptin levels were significantly higher in non-survivors (77.6 pmol/L) versus survivors (45.6 pmol/L).
  • Patients in the highest copeptin tertile had a 2.4-fold increased mortality risk.
  • Copeptin predicted 30-day mortality independently in medical ICU patients, with the highest tertile showing a 3.3-fold increased risk.

Conclusions:

  • Circulating copeptin levels at ICU admission are an independent predictor of 30-day mortality.
  • Copeptin serves as a valuable prognostic biomarker in medical intensive care settings.