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Analysis of Numerous Androgen Disruptors in Fish by Gas Chromatography Tandem Mass Spectrometry
Shaoying Liu1, Tianbin Bian1, Huali He1
1Hangzhou Center for Disease Control and Prevention, Laboratory of Chemistry and Physics, Hangzhou 310021, People's Republic of China.
Abstract:
An improved analytical method was developed for the simultaneous quantification of numerous androgen disruptors-vinclozolin, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes, chlordane, heptachlor, dieldrin, endrin, and aldrin-in fish, followed by GC with tandem MS (MS/MS). Extraction, cleanup, and MS/MS parameters of analytes were optimized. The LOQs of the analytes ranged from 0.3 to 3.7 μg/kg. Reasonable recoveries (73.7-119.2%) were demonstrated at different spike levels with RSDs lower than 12.2%. This method was applied for the analysis of the target analytes in fish samples sold in Hangzhou, China, and DDTs were found to be the predominant contaminants in fish samples.
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