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The Gender Association of the SIRT1 rs7895833 Polymorphism with Pediatric Obesity: A 3-Year Panel Study
Myoungsook Lee1, Serim Choi, Yunkyoung Lee
1Department of Food and Nutrition, Sungshin Women's University, Seoul, Republic of Korea.
Insights
Sirtuin 1 (SIRT1) gene variations are linked to pediatric obesity in Korean children. This study found differences in obesity markers and metabolic health based on SIRT1 genotypes, with a notable gender disparity.
Area of Science:
- Genetics and genomics
- Pediatric health and nutrition
- Metabolic disorders
Background:
- Sirtuin 1 (SIRT1) is a longevity-associated gene with diverse functions.
- Pediatric obesity is a growing public health concern with complex etiologies.
- Genetic variations may influence an individual's susceptibility to obesity.
Purpose of the Study:
- To investigate the association between Sirtuin 1 (SIRT1) gene variation and pediatric obesity.
- To explore potential gender-specific effects of SIRT1 genotypes on obesity parameters and metabolic profiles in children.
Main Methods:
- A longitudinal study followed 219 children (8-9 years old) for 3 years.
- Obesity parameters (anthropometrics, lipids, insulin resistance) and nutrient intake were analyzed.
- Genotyping was performed for the SIRT1 rs7895833 polymorphism (GG, GA, AA).
Main Results:
- Obesity prevalence increased from 18.3% to 25.1% over the study period.
- Children with GA+AA genotypes showed higher BMI and waist circumference compared to GG genotype.
- Gender-specific effects were observed: boys showed differential lipid changes, while girls exhibited distinct insulin resistance improvements based on genotype.
Conclusions:
- SIRT1 gene variation is associated with pediatric obesity in Korean children.
- A significant gender difference was observed in the association between SIRT1 variation and metabolic health outcomes.
Objectives:
Sirtuin 1 (SIRT1), a longevity-associated gene, has pleiotropic functions. We investigated whether SIRT1 variation is associated with pediatric obesity.
Methods:
During 3 years of follow-up of 219 children (101 boys, 118 girls) aged 8 or 9 years at baseline, obesity parameters such as anthropometrics, plasma lipid and insulin resistance profiles, and nutrient intakes were analyzed with regard to 3 genotypes of SIRT1 rs7895833 (GG, GA, and AA).
Results:
The prevalence of obesity including overweight had increased from 18.3% (in 2007) to 25.1% (in 2010), and the incidence of obesity over 3 years from nonobesity at the baseline was 11.7%. In the obesity group (BMI >85th percentile) that had been nonobese 3 years before, the frequency of the GA+AA genotypes was higher than that of the GG genotype. Among the total number of subjects, the values for criteria for obesity such as BMI and waist circumference were higher in the GA+AA group than in the GG group. In boys, the reductions in total cholesterol and low-density lipoprotein cholesterol levels in the GG group were considerably greater than those in the GA+AA group, even though the changes in carbohydrate, fat, and protein intake in the GG group were higher than in the GA+AA group. In girls, the reductions in fasting blood sugar and homeostatic model assessment insulin resistance (HOMA-IR) levels were greater in the GA+AA group than in the GG group, despite unchanged energy intakes over 3 years.
Conclusions:
We identified an association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.
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