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Updated: Mar 8, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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[Pregnancy-associated Breast Cancer].

P Tesařová

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |January 26, 2017
    PubMed
    Summary

    Pregnancy-associated breast cancer treatment can be modified for safety during pregnancy and breastfeeding. Treatment outcomes for pregnant patients are similar to non-pregnant individuals, with safe outcomes for children.

    Area of Science:

    • Oncology
    • Maternal-Fetal Medicine

    Background:

    • Pregnancy-associated breast cancer (PABC) is diagnosed during pregnancy or up to one year postpartum.
    • Management requires modifications to ensure fetal safety.

    Purpose of the Study:

    • To review the safety and efficacy of breast cancer treatments during pregnancy and breastfeeding.
    • To assess the impact of PABC on maternal and fetal outcomes.

    Main Methods:

    • Review of existing literature on PABC management.
    • Analysis of treatment protocols, including chemotherapy, surgery, radiotherapy, hormonal therapy, and biological agents.
    • Evaluation of prognostic factors and long-term outcomes for mother and child.

    Main Results:

    • Chemotherapy (anthracyclines, taxanes, cisplatin) is generally safe from the second month of pregnancy.

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  • Surgery is feasible during pregnancy; radiotherapy is not.
  • Hormonal therapy and trastuzumab are contraindicated during pregnancy.
  • Prognosis is similar to non-pregnant patients, but worse if diagnosed during breastfeeding.
  • Children show no developmental deficits; subsequent pregnancies do not negatively impact prognosis.

    • Conclusions:

    • Modified breast cancer treatments can be safely administered during pregnancy and breastfeeding.
    • Early diagnosis and appropriate management are crucial for favorable outcomes in PABC.
    • Breastfeeding after treatment is safe, though often requires using the contralateral breast.