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Related Experiment Videos

Eyelid movement abnormalities in progressive supranuclear palsy.

L I Golbe1, P H Davis, F E Lepore

  • 1Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1989
PubMed
Summary
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Progressive supranuclear palsy (PSP) can cause eyelid movement issues like blepharospasm and abnormal opening/closing. Patients with PSP have significantly fewer blinks per minute compared to Parkinson's disease patients.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease affecting eye movements.
  • Eyelid movement abnormalities are not well-characterized in PSP.

Purpose of the Study:

  • To systematically investigate eyelid movement disorders in patients with progressive supranuclear palsy.
  • To compare blink rates and patterns in PSP patients with those in Parkinson's disease patients.

Main Methods:

  • Systematic videotaping of eyelid movements in 38 community-based patients with PSP.
  • Clinical assessment of upgaze paresis and disease duration.
  • Comparison of blink rates during rest and voluntary eye movements.

Main Results:

Related Experiment Videos

  • 26% of PSP patients exhibited blepharospasm or apraxia of lid opening/closing.
  • Patients with supranuclear lid dysfunction showed more severe upgaze paresis.
  • PSP patients had a markedly lower blink rate (3.0/min) than Parkinson's disease patients (12.5/min).
  • A novel finding of "slow blinks" was observed in one PSP patient.

Conclusions:

  • Eyelid movement abnormalities are a notable feature in a significant portion of PSP patients.
  • Reduced blink rate is characteristic of PSP, distinguishing it from Parkinson's disease.
  • Synkinetic movements are employed by PSP patients to compensate for lid dysfunction.