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Pathogenicity of some Chrysosporium species isolated in France

D Chabasse1, L De Gentile, J P Bouchara

  • 1Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional, Angers, France.

Mycopathologia
|June 1, 1989
PubMed

Insights

Geophilic Chrysosporium fungi showed limited pathogenicity in experimental infections of guinea pigs and mice. While some species caused transient skin lesions or peritoneal granulomas, their pathogenic role remains uncertain, though they can persist in tissues.

Area of Science:

  • Mycology
  • Veterinary Dermatology
  • Infectious Diseases

Background:

  • Geophilic fungi, particularly Chrysosporium species, are known environmental fungi.
  • Their pathogenic potential in mammals requires further investigation.

Purpose of the Study:

  • To evaluate the pathogenicity of several geophilic Chrysosporium species in experimental animal models.
  • To assess the host response to inoculation with these fungi.

Main Methods:

  • Experimental infestations were conducted on guinea pigs and white mice.
  • Fungal inoculations were applied to the skin of guinea pigs and intraperitoneally in mice.
  • Lesion development, hair invasion, and internal tissue responses were monitored.

Main Results:

  • Guinea pigs developed rare, transient erythematous scaling lesions with no significant hair invasion.
  • Mice inoculated intraperitoneally with certain Chrysosporium species (C. keratinophilum, C. tropicum, C. state Arthroderma curreyi, C. state A. tuberculatum) developed peritoneal granulomas with necrotic centers.
  • Fungal conidia were viable in necrotic tissues, and retrocultures were positive, indicating fungal persistence.

Conclusions:

  • The pathogenicity of these geophilic Chrysosporium species is uncertain.
  • Despite limited acute pathogenicity, their ability to survive in host tissues suggests a potential for opportunistic infections under specific circumstances.

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