Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intratumoral Distribution of [<sup>177</sup>Lu]Lu-PSMA-617 Over Time and in Relation to Diagnostic Tracers in Animal Models of Prostate Cancer.

Cancer biotherapy & radiopharmaceuticals·2024
Same author

Investigating Ras homolog gene family member C (RhoC) and Ki67 expression following external beam radiation therapy show increased RhoC expression in relapsing prostate cancer xenografts.

Biochemical and biophysical research communications·2024
Same author

Preclinical efficacy of hK2 targeted [<sup>177</sup>Lu]hu11B6 for prostate cancer theranostics.

Theranostics·2019
Same author

Intraperitoneal Alpha-Radioimmunotherapy of Advanced Ovarian Cancer in Nude Mice Using Different High Specific Activities.

World journal of oncology·2017
Same author

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications-Focus on Prostate and Breast Cancer.

International journal of molecular sciences·2017
Same author

High resolution digital autoradiographic and dosimetric analysis of heterogeneous radioactivity distribution in xenografted prostate tumors.

Medical physics·2016
Same journal

Explainable incremental-value analysis of apparent diffusion coefficient and arterial spin labeling radiomics for ATRX status prediction in glioblastoma.

Frontiers in oncology·2026
Same journal

Study-level factors associated with hematoma after ultrasound-guided vacuum-assisted breast lesion excision: a systematic review and meta-analysis using a T-P-B framework.

Frontiers in oncology·2026
Same journal

Feasibility and strategy analysis of radiotherapy consolidation following immunotherapy for stage IV esophageal squamous cell carcinoma.

Frontiers in oncology·2026
Same journal

Anastomosing hemangioma of the kidney: a case report.

Frontiers in oncology·2026
Same journal

Machine learning-based prediction of prolonged air leak after uniportal video-assisted thoracic surgery segmentectomy.

Frontiers in oncology·2026
Same journal

Past present and future of radiosensitization in cervical cancer.

Frontiers in oncology·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.7K

Targeting Prostate Cancer Stem Cells with Alpha-Particle Therapy.

Jens Ceder1, Jörgen Elgqvist2

  • 1Department of Translational Medicine, Lund University, Skåne University Hospital , Malmö , Sweden.

Frontiers in Oncology
|January 26, 2017
PubMed
Summary
This summary is machine-generated.

Targeted alpha-particle therapy shows promise for eradicating radioresistant cancer stem cells (CSCs) in prostate cancer (PCa). This approach may overcome treatment resistance and improve patient outcomes by targeting CSCs responsible for tumor recurrence.

Keywords:
alpha particlescancer stem cellsprostate cancerradioimmunotherapytargeted therapy

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

981
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.7K

Related Experiment Videos

Last Updated: Mar 8, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.7K
A New Technique for Treating Low-risk Prostate Cancer&#8212;Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

981
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.7K

Area of Science:

  • Oncology
  • Radiopharmaceutical Therapy
  • Molecular Imaging and Therapy

Background:

  • Traditional targeted therapy relies on homogenous antigen expression, which may miss resistant cancer stem cells (CSCs).
  • Cancer stem cells (CSCs) drive tumor recurrence and resistance to conventional therapies, including radioresistance.
  • Prostate cancer (PCa) recurrence is often linked to therapy-resistant CSCs that evade standard treatments.

Purpose of the Study:

  • To evaluate the potential of targeted alpha-particle therapy for eradicating cancer stem cells (CSCs) in prostate cancer (PCa).
  • To discuss the parameters, advantages, and disadvantages of using alpha-particle emitting radionuclides for PCa treatment.

Main Methods:

  • Review of alpha-particle characteristics and their suitability for targeted cancer therapy.
  • Analysis of CSC biology and their role in treatment resistance and tumor recurrence.
  • Evaluation of alpha-particle emitting radionuclides for targeting CSCs in prostate cancer.

Main Results:

  • Alpha particles offer high localized energy deposition, ideal for destroying small tumor cell clusters and individual CSCs.
  • The intense DNA damage caused by alpha particles is effective against radioresistant CSCs.
  • Targeting CSCs with alpha-particle therapy may overcome resistance to conventional treatments like androgen deprivation.

Conclusions:

  • Targeted alpha-particle therapy presents a promising strategy to eliminate therapy-resistant CSCs in prostate cancer.
  • This approach could potentially cure PCa or significantly prolong survival in patients with recurrent or advanced disease.
  • Further research and consideration of specific parameters are crucial for the clinical application of alpha-particle therapy in PCa.