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Experimental patch testing with chromium-coated materials.

David Bregnbak1, Jacob P Thyssen1, Morten S Jellesen2

  • 1Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.

Contact Dermatitis
|January 26, 2017
PubMed
Summary
This summary is machine-generated.

Chromium coatings on discs can cause allergic reactions in sensitive individuals. Both chromium(VI) and chromium(III) surfaces pose a risk to patients with chromium allergy.

Keywords:
allergic chromium dermatitisallergychromiumdermatitisleathermetalspotassium dichromate

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Area of Science:

  • Dermatology
  • Allergology
  • Materials Science

Background:

  • Chromium coatings offer decorative and protective properties for metal alloys.
  • Previous research indicated chromium transfer to skin from handling chromium-containing objects.
  • Understanding potential allergic reactions to chromium surfaces is crucial for patient safety.

Purpose of the Study:

  • To investigate patch test reactivity to various chromium-coated metallic discs.
  • To assess the risk posed by different chromium valencies (III and VI) in allergic individuals.

Main Methods:

  • Patch testing was performed on 15 patients (10 chromium-allergic, 5 controls).
  • Tests included potassium dichromate, cobalt chloride, nickel sulfate, and nine metallic discs.
  • Chromium-allergic patients underwent serial dilution patch testing with potassium dichromate.

Main Results:

  • Several chromium-coated discs elicited positive or weaker patch test reactions in allergic patients.
  • A significant number of chromium-allergic patients reacted to specific concentrations of chromium(VI).
  • Dermatitis was observed in a subset of patients when exposed to both chromium(III) and chromium(VI) discs.

Conclusions:

  • Multiple patients demonstrated reactivity to both chromium(III) and chromium(VI) surfaces.
  • The study highlights that both chromium(VI) and chromium(III) present a risk to individuals with chromium allergy.
  • This underscores the need for careful consideration of chromium exposure in allergic populations.