Association study between the neurexin-1 gene and tardive dyskinesia
Rachel Lanning1, Tristram A Lett1,2, Arun K Tiwari1,3
1Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Objective:
Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.
Methods:
This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.
Results:
We did not find these SNPs to be significantly associated with TD.
Conclusions:
More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.
