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Ara h 6 sensitization in peanut allergy: friend, foe or innocent bystander?
C Tontini1, L Marinangeli2, N Maiello3
1Dipartimento di Medicina Interna, U.O. Allergologia, Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona, Ancona, Italy. Phone: +39 071 596 5693
Abstract:
The clinical role of Ara h 6 sensitization in peanut allergy is a current matter of debate. We investigated the role of Ara h 6 sensitization patterns in a sample of young adults from different Italian cities. Sera of 33 patients with specific IgE against Ara h 6 were selected. According to clinical symptoms upon peanut ingestion, patients were divided into severe reaction (SR) and mild-tolerant (MT) subgroups. While the SR group mainly showed sensitization patterns involving Ara h 2 and other major allergenic components, a previously undescribed association between Ara h 6 and Ara h 9 was found in the MT group. This pattern seems to be clustered in Mediterranean Italy and associated with Pru p 3 sensitization. This finding might shed a new light on the role of Ara h 6 sensitization in peanut allergy.
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