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Related Concept Videos

Asepsis01:28

Asepsis

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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

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Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
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SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

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SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
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Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Transfusion thresholds and red blood cells transfusion focused on tissue oxygenation.

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The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study.

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Related Experiment Video

Updated: Mar 8, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Update on surgical sepsis syndrome.

J-L Vincent1

  • 1Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.

The British Journal of Surgery
|January 26, 2017
PubMed
Summary

Sepsis, a severe infection complication in surgery, requires prompt identification and treatment. Early intervention with source control, antibiotics, and organ support improves outcomes for surgical patients.

Area of Science:

  • Surgical critical care
  • Infectious diseases
  • Immunology

Background:

  • Sepsis is a significant complication in surgical patients, linked to increased hospital stays and mortality.
  • Evolving definitions of sepsis necessitate updated understanding of its pathobiology and treatment.
  • This review examines the historical evolution of sepsis definitions and current management strategies.

Purpose of the Study:

  • To review the changing definitions of sepsis over time.
  • To provide an update on the fundamental pathobiology of sepsis.
  • To outline essential treatment modalities for surgical sepsis.

Main Methods:

  • Literature search of PubMed using terms 'surgical sepsis' and 'surgical ICU' for English publications before October 2016.

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  • Reference lists of identified articles were reviewed.
  • Relevant literature was supplemented by expert knowledge.

    • Main Results:

    • Sepsis is characterized by infection coupled with organ dysfunction, stemming from a dysregulated host response.
    • Infection prevention is key to mitigating sepsis development.
    • Treatment involves source control, antibiotics, and organ support.

    Conclusions:

    • Sepsis is a critical surgical complication requiring diligent infection prevention.
    • Rapid diagnosis and early initiation of source control, antibiotics, and organ support are vital.
    • Future advancements in classifying sepsis profiles may lead to personalized therapeutic approaches.