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Published on: June 15, 2019
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Update on surgical sepsis syndrome
1Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.
The British Journal of Surgery
|January 26, 2017
Summary
Sepsis, a severe infection complication in surgery, requires prompt identification and treatment. Early intervention with source control, antibiotics, and organ support improves outcomes for surgical patients.
Area of Science:
- Surgical critical care
- Infectious diseases
- Immunology
Background:
- Sepsis is a significant complication in surgical patients, linked to increased hospital stays and mortality.
- Evolving definitions of sepsis necessitate updated understanding of its pathobiology and treatment.
- This review examines the historical evolution of sepsis definitions and current management strategies.
Purpose of the Study:
- To review the changing definitions of sepsis over time.
- To provide an update on the fundamental pathobiology of sepsis.
- To outline essential treatment modalities for surgical sepsis.
Main Methods:
- Literature search of PubMed using terms 'surgical sepsis' and 'surgical ICU' for English publications before October 2016.
- Reference lists of identified articles were reviewed.
- Relevant literature was supplemented by expert knowledge.
Main Results:
- Sepsis is characterized by infection coupled with organ dysfunction, stemming from a dysregulated host response.
- Infection prevention is key to mitigating sepsis development.
- Treatment involves source control, antibiotics, and organ support.
Conclusions:
- Sepsis is a critical surgical complication requiring diligent infection prevention.
- Rapid diagnosis and early initiation of source control, antibiotics, and organ support are vital.
- Future advancements in classifying sepsis profiles may lead to personalized therapeutic approaches.
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