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Related Experiment Video

Updated: Mar 8, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

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Radiation Safety Considerations In GliaSite 125I Brain Implant Procedures.

Jodi Strzelczyk¹, R Safadi

¹* University of Colorado Health Sciences Center, Denver, CO 80262.

|January 26, 2017

Summary

The GliaSite Radiotherapy System, using iodine-125 seeds, is becoming standard for treating recurrent gliomas after surgery. This method allows for safe and effective radiation delivery directly to the tumor cavity.

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Area of Science:

Neurosurgery
Radiation Oncology
Medical Physics

Background:

Traditional treatment for malignant brain tumors involves permanent iodine-125 seed implantation post-resection.
A shift is occurring for unifocal recurrent gliomas, moving towards advanced radiotherapy systems.

Purpose of the Study:

To describe the GliaSite Radiotherapy System and its application in treating unifocal recurrent gliomas.
To highlight the technical, dosimetric, and logistical considerations for implementing this radiotherapy approach.

Main Methods:

Surgical placement of an inflatable balloon catheter in the tumor resection cavity.
Confirmation of balloon positioning and conformity using MRI with contrast.
Filling the balloon with liquid iodine-125 (I-125) for targeted radiation delivery.

Main Results:

The GliaSite system delivers a prescription dose of 40-60 Gy over 3-5 days using 2.77-16.6 GBq of I-125.
Successful implementation requires coordination between hospital departments and Radiation Safety Officers (RSOs).

Conclusions:

The GliaSite Radiotherapy System is evolving from a clinical trial to a standard of care for specific brain tumor recurrences.
With proper guidance and safety protocols, I-125 brachytherapy procedures can be performed safely.