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Updated: Aug 12, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Considerations in the treatment of neurological disorders with trophic factors
1School of Gerontology, University of Southern California, Los Angeles 90089-0191.
Abstract:
The rationale for the therapeutic administration of NGF in Alzheimer's disease cannot be based purely on the premise of replacement therapy, and must instead consider the general anabolic properties of this trophic substance. In addition, there are potentially deleterious side effects of such therapy which should be evaluated in clinical trials. The selectivity of NGF for cholinergic neurons (in CNS) compared to the more generalized degeneration found in Alzheimer's disease raises the possibility of using trophic factors supporting a broader variety of neuron classes (FGF, ILGF).
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