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Will neurotrophic agents be harmful in Alzheimer's disease?
S H Appel1, J L McManaman, W J Strittmatter
1Department of Neurology, Baylor College of Medicine, Houston, TX.
Neurobiology of Aging
|September 1, 1989
Abstract:
The thesis that neurotrophic therapy in Alzheimer's disease may exacerbate the pathological state merits careful experimental verification. We are concerned about prematurely dismissing an important avenue of potential therapy which would provide a trophic stimulus to compensate for enhanced proteolysis and the deposition of A4 amyloid peptide.