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Related Experiment Video

Updated: Mar 8, 2026

Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
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Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

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Zika Virus Targeting in the Developing Brain.

Anthony N van den Pol1, Guochao Mao2, Yang Yang2

  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 anthony.vandenpol@yale.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 27, 2017
PubMed
Summary

Zika virus (ZIKV) can infect the developing brain, initially targeting astrocytes and visual system cells. The virus spreads via axonal transport, highlighting complex CNS targeting and potential astrocyte importance in ZIKV infection.

Keywords:
astrocytebehavior dysfunctiondevelopmentinfectionneurotropicvirus

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Zika Virus Infection of Cultured Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis
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Area of Science:

  • Neuroscience
  • Virology
  • Developmental Biology

Background:

  • Zika virus (ZIKV) poses significant risks to neurological development, causing issues like microcephaly.
  • ZIKV infection can impact the brain during both early and later fetal/neonatal developmental stages.
  • Previous understanding of ZIKV's initial cellular targets in the brain is limited.

Purpose of the Study:

  • To investigate the cellular tropism and spread of Zika virus in the developing central nervous system (CNS).
  • To understand the role of astrocytes and axonal transport in ZIKV pathogenesis.
  • To utilize a newborn mouse model that mimics second-trimester human fetal brain development.

Main Methods:

  • Peripheral inoculation of newborn immunocompetent mice with ZIKV.
  • ZIKV microinjection into the somatosensory cortex of mature mice, including those lacking Type 1 interferon response (IFNR-/-).
  • Immunohistochemical analysis to detect ZIKV immunoreactivity in various brain regions and retinal cells.

Main Results:

  • ZIKV successfully entered the CNS in all developing mice after peripheral inoculation, initially targeting astrocytes.
  • Infection of retinal neurons was detected in all developing mice, with common involvement of visual system nuclei.
  • Axonal transport of ZIKV was observed, leading to infection in synaptically connected contralateral brain regions.

Conclusions:

  • Zika virus exhibits complex targeting within the CNS, affecting different cell types at various developmental stages.
  • Astrocytes appear to be a primary initial target for ZIKV in the developing brain.
  • Axonal transport contributes to ZIKV's spread within the brain, underscoring the virus's potential for widespread neurological damage.