[Osteoporosis in Super-aged society.]

Area of Science:

• Gerontology
• Internal Medicine
• Pharmacology

Background:

• Osteoporosis is a significant health concern, potentially increasing the risk of comorbid conditions such as cardiovascular events.
• This increased comorbidity in osteoporosis patients is associated with elevated mortality rates.

Purpose of the Study:

• To evaluate the impact of antiresorptive agents on mortality and quality of life in patients with osteoporosis.
• To assess the efficacy of bisphosphonates in mitigating fracture risk and improving overall survival.

Main Methods:

• Review of studies investigating antiresorptive agents, specifically bisphosphonates.
• Analysis of data on fracture incidence, all-cause mortality, and quality of life metrics.

Main Results:

• Antiresorptive agents, including bisphosphonates, have demonstrated a reduction in osteoporotic fractures.
• These medications are associated with a decrease in all-cause mortality among treated patients.
• Improvements in quality of life and activities of daily living are anticipated with long-term use.

Conclusions:

• Antiresorptive therapy, particularly bisphosphonates, offers a dual benefit in managing osteoporosis by reducing fractures and mortality.
• These treatments hold promise for enhancing patient longevity and functional independence.