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High-dose anti-histamine use and risk factors in children with urticaria

Pınar Uysal1, Sibelnur Avcil2, Duygu Erge1

  • 1Division of Pediatric Allergy and Clinical Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.

Turk Pediatri Arsivi
|January 27, 2017
PubMed

Insights

Children with chronic urticaria, especially those aged 10 and older, often require higher doses of H1-antihistamines. Disease severity and low basophil counts are key risk factors for this increased need.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Clinical Pharmacology

Background:

  • Urticaria is a common condition in children, primarily managed with H1-antihistamines.
  • Identifying factors influencing treatment response is crucial for optimizing care.

Purpose of the Study:

  • To evaluate risk factors associated with the need for high-dose H1-antihistamines in pediatric urticaria.
  • To analyze differences between acute and chronic urticaria in children.

Main Methods:

  • Retrospective analysis of medical data from 230 children with urticaria (2014-2016).
  • Recorded variables included demographics, atopic history, blood counts (eosinophils, basophils), IgE levels, and urticaria activity scores (UAS7).
  • Evaluated autoimmune markers and skin prick tests in chronic urticaria cases.

Main Results:

  • Chronic urticaria was more prevalent in older children (≥10 years) and associated with higher H1-antihistamine requirements.
  • No significant differences in eosinophil, basophil counts, or total IgE between acute and chronic groups.
  • Higher UAS7 scores and basopenia were identified as significant risk factors for requiring high-dose H1-antihistamines in chronic urticaria.

Conclusions:

  • Increasing age is linked to a higher need for high-dose H1-antihistamines in pediatric urticaria.
  • Disease severity (UAS7) and basopenia are significant predictors of high-dose H1-antihistamine requirement.
Abstract

Keywords:
Acute urticariaantihistaminechronic urticariapediatricstreatmenturticaria

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