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Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success

Juan Pablo Jaworski1, Alejandrina Vendrell2, Sebastián Matias Chiavenna3

  • 1National Scientific and Technical Research Council, Buenos Aires, Argentina; Institute of Virology, National Institute of Agricultural Technology, Castelar, Buenos Aires, Argentina.

Frontiers in Immunology
|January 27, 2017
PubMed

Anti-human immunodeficiency virus type-1 (anti-HIV-1) neutralizing monoclonal antibodies are broadening the spectrum of pre- and post-exposure treatment against HIV-1. A better understanding of how these antibodies develop and interact with particular regions of the viral envelope protein is guiding a more rational structure-based immunogen design. The aim of this article is to review the most recent advances in the field, from the development of these particular antibodies during natural HIV-1 infection, to their role preventing infection, boosting endogenous immune responses and clearing both free viral particles and persistently infected cells.

Keywords:
human immunodeficiency virusneutralizing antibodiesprophylaxisreservoirtreatmentvaccine

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