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Updated: Mar 8, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Apolipoprotein E polymorphisms increase the risk of post-stroke depression.

Xue-Bin Li1, Jie Wang2, An-Ding Xu3

  • 1Stroke Center & Neurology Division, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China; Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China.

Neural Regeneration Research
|January 27, 2017
PubMed
Summary

The apolipoprotein E (APOE) rs429358 polymorphism increases the risk of post-stroke depression. This genetic factor may negatively impact nerve function recovery and is linked to higher cholesterol levels.

Keywords:
apolipoprotein Ecerebral infarctiongenetic polymorphismnerve regenerationneural regenerationpost-stroke depressionregional resting-state cerebral blood flowriskrs429358rs7412

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Apolipoprotein E (APOE) polymorphisms are implicated in neurodegenerative diseases.
  • The role of APOE in post-stroke depression (PSD) remains unclear.
  • This study investigates the association between APOE polymorphisms and PSD risk.

Purpose of the Study:

  • To determine if APOE rs429358 and rs7412 polymorphisms are associated with the risk of post-stroke depression.
  • To explore the relationship between APOE rs429358 and clinical outcomes in stroke patients.

Main Methods:

  • A hospital-based case-control study was conducted.
  • Participants included cerebral infarction cases with and without PSD, and healthy controls.
  • Genotyping for APOE rs429358 and rs7412 polymorphisms was performed.

Main Results:

  • No significant difference in rs7412 genotype distribution was observed among groups.
  • APOE genotypes with the rs429358-C allele were associated with an increased risk of PSD.
  • The rs429358 polymorphism correlated with reduced left temporal lobe cerebral blood flow, increased depression severity, and elevated total cholesterol levels.

Conclusions:

  • The APOE rs429358 polymorphism is linked to a higher risk of developing post-stroke depression.
  • APOE rs429358-C allele genotypes may impair nerve function recovery post-stroke.
  • Findings offer clinical insights for future gene-targeted interventions for PSD.