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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Does abstinence resolve poor sleep quality in former methamphetamine dependents?
Amir Rezaei Ardani1, Seyyed Ali Saghebi1, Mahsa Nahidi1
1Psychiatry and Behavioural Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sleep quality significantly improves for methamphetamine-dependent patients after four weeks of abstinence. This improvement in sleep quality during early remission is largely independent of changes in anxiety and depressive symptoms.
Area of Science:
- Neuroscience
- Psychiatry
- Sleep Medicine
Background:
- Stimulants like amphetamines significantly impact sleep.
- Limited research exists on sleep quality during methamphetamine withdrawal.
Purpose of the Study:
- To evaluate changes in sleep quality in methamphetamine-dependent patients during early remission.
- To control for depression and anxiety as potential confounding variables affecting sleep quality.
Main Methods:
- Ninety methamphetamine-dependent patients in residential centers were assessed.
- Sleep quality was measured using the Pittsburgh Sleep Quality Questionnaire at weeks 1, 2, and 4 of abstinence.
- Depression and anxiety were assessed using Beck Depression Inventory-2 and Beck Anxiety Inventory.
Main Results:
- The prevalence of poor sleep quality decreased from 97.8% in the first week to 52.2% at four weeks post-abstinence (P=0.00).
- Variations in depression and anxiety had a minimal impact on sleep quality changes (adjusted R2<0.5).
- The influence of anxiety and depression on sleep quality diminished over time.
Conclusions:
- Methamphetamine withdrawal patients experience significant sleep quality improvement after four weeks of abstinence.
- Sleep quality improvement during early remission is independent of concurrent changes in anxiety and depressive symptoms.
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