Related Experiment Video
Updated: Mar 8, 2026
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Serum C-reactive protein, fibrinogen and D-dimer in patients with progressive cerebral infarction
Ruo-Shi Zang1, Hong Zhang1, Yan Xu1
1Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Insights
Dynamic changes in C-reactive protein (CRP), fibrinogen (FIB), and D-dimer (D-D) help identify progressive cerebral infarction. Monitoring these biomarkers aids in early detection and treatment of ischemic strokes.
Area of Science:
- Neurology
- Biochemistry
- Vascular Medicine
Background:
- Progressive cerebral infarctions lead to increased mortality and disability.
- Mechanisms underlying progressive cerebral infarction require further elucidation.
Purpose of the Study:
- To investigate dynamic changes in serum C-reactive protein (CRP), fibrinogen (FIB), and D-dimer (D-D).
- To better characterize progressive cerebral infarction using these biomarkers.
Main Methods:
- Serum CRP, FIB, and D-D levels were measured in 82 progressive and 186 non-progressive cerebral infarction patients.
- Measurements were taken on days 1, 3, 7, and 14 post-admission.
- Carotid vascular ultrasound and NIHSS scores were also recorded.
Main Results:
- Progressive group had higher carotid stenosis and significantly elevated CRP, FIB, and D-D levels on days 3, 7, and 14.
- The progressive group showed increasing NIHSS scores, unlike the non-progressive group.
- All observed differences between groups were statistically significant (P < 0.01).
Conclusions:
- Changes in CRP, FIB, and D-D levels correlate with progressive cerebral infarction.
- Monitoring these biomarkers may facilitate early identification of progressing ischemic strokes.
- Timely treatment strategies can be informed by these dynamic biomarker changes.
Objective:
Progressive cerebral infarctions increase mortality and functional disability through mechanisms which have yet to be completely understood. The goal of this study was to explore the dynamic changes of serum C-reactive protein (CRP), fibrinogen (FIB) and D-dimer (D-D) in order to better characterize progressive cerebral infarction.
Methods:
The amount of serum CRP, FIB and D-D was measured in 82 patients with progressive cerebral infarction by taking samples from the internal carotid artery (progressive group), and in 186 patients with non-progressive cerebral infarction (non-progressive group) by using an automatic biochemical analyzer during the next day (day 1), day 3, day 7, and day 14 after being admitted to hospital. Carotid vascular ultrasound and neurological deficit score (National Institutes of Health Stroke Scale, NIHSS) were also recorded.
Results:
Carotid stenosis ratio was significantly higher in the progressive group than in the non-progressive group (P < 0.01) on admission. In the progressive group, CRP increased significantly on day 3, followed by a decline on day 7 and day 14, but was significantly higher than those in the non-progressive group (P < 0.01). The levels of FIB and D-D increased in the progressive group more than those in the non-progressive group on day 3, day 7, and day 14 (P < 0.01). The progressive group patients' NIHSS score gradually increased after admission, which was opposite to the non-progressive group patients whom followed a downward trend. The difference between these two groups was significant (P < 0.01).
Conclusion:
Observing changes of CRP, FIB and D-D may contribute to early identification and timely treatment of progressing ischemic strokes.
More Related Videos
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies