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Updated: Mar 8, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Hypoxia and antitumor CD8+ T cells: An incompatible alliance?
Romain Vuillefroy de Silly1, Pierre-Yves Dietrich2, Paul R Walker2
1Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Ludwig Center for Cancer Research of the University of Lausanne, Biopôle III, Epalinges, Switzerland.
Abstract:
T Lymphocytes face pathologically low O2 tensions within the tumor bed at which they will have to function in order to impact on the malignancy. Recent studies highlighting the importance of O2 and hypoxia-inducible factors for CD8+ T-cell function and fate must now be integrated into tumor immunology concepts if immunotherapies are to progress. Here, we discuss, reinterpret, and reconcile the many apparent contradictions in these data and we propose that O2 is a master regulator of the CD8+ T-cell response. Certain T cell functions are enhanced, others suppressed, but on balance, hypoxia is globally detrimental to the antitumor response.
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