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Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose

Lars Stechemesser1, Sebastian K Eder2, Andrej Wagner1

  • 1First Department of Medicine, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria.

Molecular Metabolism
|January 27, 2017
PubMed
Abstract

Keywords:
+Fe, with iron overloadALT, alanine aminotransferaseAST, aspartate aminotransferaseAkt/PKB, Akt/protein kinase BBMI, body mass indexCDP, CytidinediphosphatCRP, C-reactive proteinDIOS, dysmetabolic iron overload syndromeFoxO1, forkhead transcription factor O1GGT, gamma-glutamyl transpeptidaseGLUT1, glucose transporter 1GNMT, glycine N-methyltransferaseGSK3β, glycogen synthase kinase 3βGlucoseHDL, high density lipoproteinsHIF1α, hypoxia-inducible factor 1αHOMA-IR, homeostatic model assessment-insulin resistanceHyperferritinemiaIL, interleukinIR, insulin resistanceIron overloadLDL, low density lipoproteinsMRI, magnet resonance imagingMetS, metabolic syndromeMetabolic syndromeMetabolomicsNAFLD, non-alcoholic fatty liver diseasePC, phosphatidylcholinePCOS, polycystic ovary syndromePC_E, plasmalogensPEMT, phosphatidylethanolamine N-methyltransferaseRBC, red blood countT2D, type 2 diabetes mellitusTNF, tumor necrosis factorVLDL, very low-densitylipoproteinsWHO, World Health OrganizationWHR, waist hip ratiooGTT, oral glucose tolerance test−Fe, without iron overload

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