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Use of novel oral anticoagulant agents in venous thromboembolism

Shivanshu Madan1, Shenil Shah2, Patrick Dale3

  • 1Department of Cardiovascular Medicine, University of North Carolina Hospitals, Chapel Hill, NC, USA.

Cardiovascular Diagnosis and Therapy
|January 27, 2017
PubMed

Insights

New oral anticoagulants (NOACs) offer alternatives to warfarin for preventing and treating venous thromboembolic (VTE) disease. This review covers their clinical use and trial data on safety and efficacy for cardiovascular practitioners.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Warfarin has been the standard for venous thromboembolic (VTE) disease treatment.
  • Newer anticoagulants offer potential advantages in administration and monitoring.

Purpose of the Study:

  • To review the clinical utility of new oral anticoagulants (NOACs).
  • To summarize landmark trials evaluating NOAC safety and efficacy.
  • To inform cardiovascular practitioners managing VTE patients.

Main Methods:

  • Review of clinical trials on NOACs.
  • Analysis of safety and efficacy data.
  • Summary of clinical applications.

Main Results:

  • NOACs demonstrate comparable or superior efficacy to warfarin in VTE prevention and treatment.
  • NOACs generally show a favorable safety profile with reduced risk of major bleeding in certain contexts.
  • Specific NOACs have different dosing and reversal strategies.

Conclusions:

  • NOACs are effective alternatives to warfarin for VTE management.
  • Understanding NOACs is crucial for optimal patient care in VTE.
  • Ongoing research will further refine the role of NOACs in cardiovascular practice.
Keywords:
Warfarinapixabandabigatrandeep veinedoxabanpulmonary embolism (PE)rivaroxabanthrombosis

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