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Cross-linking to improve THR wear performance.

R D Crowninshield1, M P Laurent, J Q Yao

  • 1Zimmer, Inc., Warsaw, Indiana USA.

Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
|January 27, 2017
PubMed
Summary
This summary is machine-generated.

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Extensively cross-linking polyethylene significantly reduces wear in total hip replacements, potentially extending implant longevity. Further clinical studies are needed to confirm these findings in living patients.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Polymer Chemistry

Background:

  • Polyethylene wear and osteolysis are primary concerns limiting total hip replacement (THR) longevity.
  • Recent advancements in polyethylene processing have improved wear resistance and component lifespan.
  • Further reductions in wear are desirable to enhance long-term implant survival.

Purpose of the Study:

  • To investigate the potential of extensively cross-linked polyethylene to further reduce wear in total hip replacements.
  • To evaluate the effectiveness of electron beam irradiation and annealing on polyethylene properties.

Main Methods:

  • GUR 1050 polyethylene was cross-linked using 100 kGy electron beam radiation.
  • Components underwent annealing to promote cross-linking and reduce free radicals.

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  • Wear testing was performed using a hip simulator.

    • Main Results:

    • Cross-linking GUR 1050 polyethylene resulted in an order of magnitude reduction in wear.
    • The process involved electron beam irradiation followed by annealing.
    • This method demonstrated significant wear reduction in laboratory testing.

    Conclusions:

    • Extensively cross-linked polyethylene shows promise for substantially reducing wear in total hip replacements.
    • This material modification could lead to improved longevity of hip implants.
    • Clinical investigation is necessary to validate the in vivo performance of these advanced materials.