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Mouse Models Of Helicobacter Infection And Gastric Pathologies
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Species-specific immunity to Helicobacter suis.

Iris Bosschem1, Bram Flahou1, Kim Van Deun1

  • 1Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

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|January 27, 2017
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Summary

Helicobacter suis evades immune responses by promoting a regulatory T-cell (Treg) biased response. This mechanism helps the bacteria persist in the stomach, despite host inflammatory reactions.

Keywords:
Helicobacter suisBALB/c micePigimmune response

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Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Helicobacter suis is a prevalent gastric pathogen in humans and pigs, distinct from H. pylori.
  • Unlike H. pylori, H. suis lacks major known virulence factors, necessitating investigation into its immune evasion strategies.

Purpose of the Study:

  • To investigate the immune evasion mechanisms employed by Helicobacter suis.
  • To understand the host immune response to H. suis infection in both murine and porcine models.

Main Methods:

  • Monitoring cytokine expression in the stomachs of H. suis-infected mice and pigs.
  • Analyzing the impact of H. suis on murine and porcine dendritic cell (DC) maturation.
  • Assessing the ability of H. suis-affected DCs to stimulate T-cell responses.

Main Results:

  • Murine Th17/Th2 responses failed to clear H. suis infection; H. suis-stimulated DCs induced IL-17 secretion.
  • In pigs, H. suis infection increased IL-17 and IL-10 mRNA expression.
  • Porcine DCs showed impaired MHCII expression and induced T-cells with increased Treg markers (TGF-β, FoxP3).

Conclusions:

  • Helicobacter suis may evade host immunity by inducing a regulatory T-cell (Treg)-biased immune response.
  • Impaired DC function in pigs contributes to a Treg-skewed environment, facilitating persistent infection.