Related Experiment Video
Updated: Mar 8, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Vitamin D3 supplementation and cellular calcium homeostasis in patients with chronic kidney disease]
Abstract:
Mini review summarizes the results of our studies focused on elucidation of the pathophysiological mechanisms of altered calcium homeostasis in nonexcitable cells from patients with early stages of chronic kidney disease (CKD), as well as on determining the effect of vitamin D3 supplementation on these mechanisms. The basic mechanisms of calcium entry to and removal of the cell are already changed in early stages of CKD. These disturbances cause an increased the concentration of cytosolic free calcium ([Ca2+]i), which may change a number of cellular processes, and the expression of various signaling molecules. Vitamin D3 supplementation is a standard procedure of vitamin D insufficiency/ deficiency correction in these patients. The pleiotropic effects of vitamin D may be involved in the modulation of cellular calcium homeostasis. Vitamin D3 supplementation resulted in a reduction in [Ca2+]i by affecting of specific transport systems of calcium cations entry to and removal of the cell. The normalization [Ca2+]i can have a beneficial effect on intracellular signalling, and thus positively influence the functioning of cells, tissues or organs.Key words: cellular calcium homeostasis - chronic kidney disease - intracellular calcium - vitamin D.
More Related Videos
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Skeleton and Calcium Homeostasis
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Chronic Kidney Disease II: Clinical Manifestations
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Chronic Kidney Disease IV: Nursing Management

