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Published on: December 28, 2011
Cholecystokinin in rat olfactory bulb is mainly contained in intrinsic neurons
C Bönnemann1, A Holland, D K Meyer
1Department of Pharmacology, University of Freiburg, F.R.G.
Abstract:
Of all lesions tested, only a knife cut at the border between the olfactory bulb and the anterior olfactory nucleus decreased cholecystokinin-like immunoreactivity in the bulb (by 50%). At the same time, the bulbar concentration of preprocholecystokinin-mRNA was reduced by 60%, indicating that reduced peptide synthesis was the cause of diminished cholecystokinin immunoreactivity. Thus, cholecystokinin immunoreactivity in rat olfactory bulb seems to be mainly contained in intrinsic neurons. The contribution of afferents seems to be minimal. In addition, the lesion induced a transient decrease in the concentration of preprocholecystokinin mRNA in the anterior olfactory nucleus of both sides, exemplifying the intricate connections between olfactory areas of both sides.
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