Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

1.1K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.1K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Bioremediation00:46

Bioremediation

22.7K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
22.7K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

1.4K
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Science must be seen as a viable profession for the many, not the few.

Nature·2026
Same author

The role of Neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in MS and AQP4-NMOSD: Advancing clinical applications.

eNeurologicalSci·2025
Same author

De Novo Hypercalcaemia in a Patient With Chronic Hypoparathyroidism.

Cureus·2025
Same author

Prions: structure, function, evolution, and disease.

Archives of microbiology·2024
Same author

Investigating the antimicrobial and antibiofilm properties of marine halophilic Bacillus species against ESKAPE pathogens.

Environmental microbiology reports·2024
Same author

Solving the protein folding problem….

FEBS letters·2024

Related Experiment Video

Updated: Mar 8, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

15.1K

Engineered Probiotics: Applications and Biological Containment.

Babasola Sola-Oladokun1, Eamonn P Culligan1, Roy D Sleator1,2

  • 1Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland; email: b.sola-oladokun@mycit.ie , eamonn.culligan@cit.ie , roy.sleator@cit.ie.

Annual Review of Food Science and Technology
|January 27, 2017
PubMed
Summary

Bioengineered probiotics are advanced biotherapeutics. Synthetic biology enables enhanced probiotics for targeted drug delivery, pathogen neutralization, and vaccine applications, with a focus on future development and containment.

Keywords:
biological containmentbiotherapeuticscancerprobioticssynthetic biologyvaccines

More Related Videos

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

4.4K
Bioreactor Assembly for Continuous Culture of Complex Fecal Communities
09:37

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Published on: April 25, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 8, 2026

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon
15:28

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

Published on: November 16, 2012

15.1K
Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

4.4K
Bioreactor Assembly for Continuous Culture of Complex Fecal Communities
09:37

Bioreactor Assembly for Continuous Culture of Complex Fecal Communities

Published on: April 25, 2025

1.3K

Area of Science:

  • Microbiology
  • Biotechnology
  • Synthetic Biology

Background:

  • Probiotics are increasingly recognized for their therapeutic potential.
  • Advances in genetic engineering and synthetic biology have opened new avenues for probiotic development.
  • Current probiotics offer a platform for novel biotherapeutic strategies.

Purpose of the Study:

  • To review significant advances in the development of bioengineered probiotics.
  • To discuss the critical issue of biological containment for engineered probiotics.
  • To consider the role of synthetic biology in designing future probiotics.

Main Methods:

  • Review of recent literature on synthetic biology and probiotic engineering.
  • Analysis of advancements in genome engineering, DNA synthesis, and sequencing.
  • Discussion of biological containment strategies for genetically modified organisms.

Main Results:

  • Bioengineered probiotics demonstrate enhanced stress tolerance.
  • Engineered probiotics can target specific pathogens and toxins.
  • Probiotics can be designed for targeted delivery of vaccines, drugs, and immunomodulators.

Conclusions:

  • Bioengineered probiotics represent a significant advancement in biotherapeutics.
  • Synthetic biology is crucial for the design and construction of next-generation probiotics.
  • Biological containment remains a critical consideration for the safe deployment of engineered probiotics.