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ECMO for Pediatric Lung Transplantation.

Monica C Olsen1, Mark J Anderson, James J Fehr

  • 1From the *The Heart Center at St. Louis Children's Hospital, St. Louis, Missouri; and Departments of †Pediatrics and Anesthesiology and ‡Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 27, 2017
PubMed
Summary
This summary is machine-generated.

Extracorporeal membrane oxygenation (ECMO) offers a promising alternative to cardiopulmonary bypass in pediatric lung transplantation, potentially reducing complications and improving outcomes. This study details four successful pediatric cases, highlighting effective perfusion management strategies.

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Area of Science:

  • Cardiovascular Surgery
  • Pulmonary Medicine
  • Pediatric Critical Care

Background:

  • Extracorporeal membrane oxygenation (ECMO) is an established alternative to cardiopulmonary bypass (CPB) in adult lung transplantation.
  • Existing literature primarily focuses on adult applications, reporting benefits like reduced pulmonary and renal complications, and lower mortality rates.

Observation:

  • This study presents the first reported series of pediatric lung transplantations utilizing ECMO.
  • Four pediatric lung transplant procedures were successfully performed using ECMO support.
  • The focus was on managing perfusion during these complex pediatric cases.

Findings:

  • ECMO can be effectively employed in pediatric lung transplantation, mirroring the positive outcomes seen in adults.
  • Successful implementation involved careful consideration and management of perfusion parameters specific to pediatric physiology.
  • The use of ECMO in this cohort was associated with manageable complications and successful graft function.

Implications:

  • ECMO represents a viable and potentially beneficial alternative to CPB for pediatric lung transplantation.
  • Further research into optimized ECMO perfusion strategies for pediatric recipients is warranted.
  • This approach may expand treatment options and improve survival rates for children requiring lung transplants.