Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

688
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
688

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[<sup>11</sup>C]PS13 PET shows that age is positively correlated with constitutively expressed cyclooxygenase-1 in the brain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Correction: Expansion of forest cover and coeval shifts in Later Stone Age land-use at Taforalt and Rhafas Caves, Morocco, as inferred from carbon isotopes in ungulate tooth enamel.

PloS one·2025
Same author

Translocator protein (TSPO) positron emission tomography imaging and expression in patients with brain metastases.

European journal of nuclear medicine and molecular imaging·2025
Same author

TSPO circadian pattern: a test-retest study of [<sup>11</sup>C]ER176.

European journal of nuclear medicine and molecular imaging·2025
Same author

Expansion of forest cover and coeval shifts in Later Stone Age land-use at Taforalt and Rhafas Caves, Morocco, as inferred from carbon isotopes in ungulate tooth enamel.

PloS one·2025
Same author

Cyclooxygenase-1 and cyclooxygenase-2 densities measured using positron emission tomography are not altered in the brains of individuals with stable multiple sclerosis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025
Same journal

Modeling and analysis of forward and inverse kinematics for a flexible Stewart platform.

PloS one·2026
Same journal

Barriers and facilitators to healthcare utilization amongst people living with sickle cell disease in the United States: A scoping review.

PloS one·2026
Same journal

Enhancing data completeness in time series: Imputation strategies for missing data using significant periodically correlated components.

PloS one·2026
Same journal

Key targets and mechanisms by which gut microbiota-derived metabolites regulate Alzheimer's disease through the immune - inflammatory pathway: Based on network pharmacology and molecular docking.

PloS one·2026
Same journal

Grid-tied Transformer-less Boost Switched Capacitor Topology (TLBSCT) for PV applications.

PloS one·2026
Same journal

The load-velocity profiles and exercise-specific velocity zones for seven commonly used weightlifting exercises.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.6K

Standardized Input Function for 18F-FDG PET Studies in Mice: A Cautionary Study.

Marie Meyer1,2, Lucie Le-Bras1, Philippe Fernandez1,2

  • 1Department of Nuclear Medicine, Pellegrin Hospital, Bordeaux, France.

Plos One
|January 27, 2017
PubMed
Summary
This summary is machine-generated.

A standardized arterial input function (SAIF) for 18F-FDG PET studies in mice shows low bias but high variability, regardless of fasting state. Image-derived input functions may be superior for mice PET imaging.

More Related Videos

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

19.9K
Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

14.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.6K
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

19.9K
Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

14.4K

Area of Science:

  • Nuclear medicine
  • Preclinical imaging
  • Pharmacokinetics

Background:

  • Positron emission tomography (PET) is crucial for preclinical research.
  • Accurate quantification in mice PET studies relies on reliable arterial input function (AIF) measurements.
  • Standardized arterial input function (SAIF) offers a potential simplification for AIF determination.

Purpose of the Study:

  • To evaluate the accuracy of a standardized arterial input function (SAIF) for 18F-FDG PET studies in mice.
  • To determine if a single SAIF is applicable across different mouse fasting conditions.
  • To compare SAIF-derived glucose metabolic rates (CMRglc) with reference values.

Main Methods:

  • SAIF was developed from fasting mice and validated.
  • SAIF was prospectively applied to non-fasting mice.
  • SAIFs were scaled using a single blood sample post-injection.
  • Calculated CMRglc values were compared to those obtained via full arterial sampling (AIF).

Main Results:

  • CMRglc values exhibited minimal bias but significant variability in both fasting and non-fasting mice.
  • The SAIF/AIF CMRglc ratio was 0.97 ± 0.22 in fasting mice and 1.04 ± 0.22 in non-fasting mice.
  • Variability stemmed from instances where SAIF inaccurately estimated the AIF shape.

Conclusions:

  • SAIF provides 18F-FDG input function estimation in mice with negligible bias, irrespective of fasting status.
  • Individual mouse errors (up to 30-50%) lead to substantial variability in CMRglc quantification.
  • Image-derived input function (IDIF) may be a more suitable alternative for mice PET studies.