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Related Experiment Video

Updated: Mar 8, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Skin-derived TSLP systemically expands regulatory T cells.

Theresa M Leichner1, Atsushi Satake2, Victor Sanoe Harrison3

  • 1Department of Pathology & Laboratory Medicine, University of Pennsylvania, United States.

Journal of Autoimmunity
|January 28, 2017
PubMed
Summary
This summary is machine-generated.

Topical vitamin D analog MC903 stimulates skin to produce TSLP, expanding regulatory T cells (Tregs) systemically. This approach shows promise for treating autoimmune diseases by modulating immune responses.

Keywords:
ImmunotherapyRegulatory T cellsThymic stromal lymphopoietinToleranceVitamin D

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Area of Science:

  • Immunology
  • Dermatology
  • Autoimmunity

Background:

  • Regulatory T cells (Tregs) are crucial for immune homeostasis and preventing autoimmune diseases.
  • Expanding Treg populations is a potential therapeutic strategy for autoimmune conditions.

Purpose of the Study:

  • To investigate the skin's capacity to systemically expand Treg numbers.
  • To explore the role of vitamin D receptor (VDR) stimulation in Treg expansion.
  • To evaluate the therapeutic potential of skin-targeted VDR stimulation for autoimmune diseases.

Main Methods:

  • Mice were treated topically with the VDR agonist MC903.
  • Flow cytometry was used to quantify Treg populations.
  • Mechanisms of Treg expansion involving thymic stromal lymphopoietin (TSLP) and dendritic cells were investigated.
  • Disease incidence and severity were assessed in models of autoimmune diabetes and experimental autoimmune encephalomyelitis.

Main Results:

  • Topical MC903 treatment led to a significant, systemic expansion of Tregs.
  • This expansion was dependent on TSLP receptor signaling and mediated by skin-derived TSLP acting on dendritic cells.
  • MC903 treatment reduced the incidence of autoimmune diabetes and attenuated experimental autoimmune encephalomyelitis severity.

Conclusions:

  • The skin can be stimulated to systemically increase Treg numbers via TSLP production.
  • Vitamin D-mediated stimulation of the skin offers a novel therapeutic strategy for autoimmune diseases.
  • Targeting skin immunity presents a promising avenue for modulating systemic immune responses.