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Mapping how local perturbations influence systems-level brain dynamics.

Leonardo L Gollo1, James A Roberts2, Luca Cocchi1

  • 1QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Neuroimage
|January 28, 2017
PubMed
Summary
This summary is machine-generated.

Local brain stimulation effects depend on a region's position in the cortical hierarchy. Peripheral brain regions, unlike central hubs, show greater impact on functional connectivity and brain network dynamics.

Keywords:
Brain networksBrain simulationComputational modelingConnectivityConnectomicsCore-periphery axisFunctional magnetic resonance imaging (fMRI)HubsKuramoto modelTranscranial magnetic stimulation (TMS)

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • The human brain's spatiotemporal organization supports function and is modifiable by local stimulation.
  • Local cortical perturbations are integrated by neural systems, but their large-scale effects are not fully understood.

Purpose of the Study:

  • To investigate how localized changes in neural activity impact large-scale brain dynamics.
  • To analyze a computational model of brain dynamics to understand stimulation effects.

Main Methods:

  • Systematic analysis of a large-scale brain dynamics model.
  • Assessment of localized activity changes across different brain regions.
  • Review of empirical and computational studies on localized brain perturbations.

Main Results:

  • Local stimulation effects correlate with a region's hierarchical position, described by smooth tuning curves.
  • Brain hubs (slower activity) are resilient to perturbations, maintaining global stability.
  • Peripheral regions (faster activity) exhibit greater impact on functional connectivity.

Conclusions:

  • A periphery-to-core hierarchy dictates the influence of local stimulation on brain networks.
  • Peripheral systems (e.g., visual, sensorimotor) are more sensitive to perturbations than high-level systems (e.g., cingulo-opercular).
  • Findings offer insights for non-invasive brain stimulation strategies to modulate functional connectivity.