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Related Experiment Video

Updated: Mar 8, 2026

Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
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Basilar Artery Changes in Fabry Disease.

R Manara1, R Y Carlier2, S Righetto3

  • 1From the Sezione di Neuroscienze (R.M.), University of Salerno, Salerno, Italy.

AJNR. American Journal of Neuroradiology
|January 28, 2017
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Summary
This summary is machine-generated.

Fabry disease causes significant basilar artery remodeling, including increased diameter and length, particularly in males. This remodeling varies with age and sex, offering insights into Fabry disease

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Area of Science:

  • Neurology
  • Vascular Biology
  • Genetics

Background:

  • Fabry disease is associated with basilar artery dolichoectasia.
  • Previous studies have limited data on the prevalence, severity, and progression of basilar artery changes in Fabry disease.

Purpose of the Study:

  • To quantitatively assess basilar artery parameters in a large cohort of Fabry disease patients using MRA.
  • To compare these parameters between Fabry disease patients and controls.

Main Methods:

  • Retrospective analysis of 1.5T MRA scans from 110 Fabry disease patients and 108 controls.
  • Measurement of basilar artery mean diameter, curved length, linear length, and tortuosity index.

Main Results:

  • Fabry disease patients exhibited increased basilar artery mean diameter and linear length compared to controls.
  • Basilar artery dimensions showed age-dependent changes, with significant differences observed in male Fabry disease patients.
  • Male Fabry disease patients had more pronounced increases in diameter, curved length, and tortuosity compared to females and male controls.

Conclusions:

  • The basilar artery undergoes significant remodeling in Fabry disease, influenced by age and sex.
  • These findings provide valuable insights into the pathophysiology of cerebral vasculature in Fabry disease.