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Circulating immune complex studies on patients with oral lichen planus
1Department of Maxillo-facial Surgery and Dentistry, Semmelweis Medical University, School of Dentistry.
Oral Surgery, Oral Medicine, and Oral Pathology
|November 1, 1989
Summary
Circulating immune complexes (CIC) may result from oral lichen planus (OLP) itself. However, diabetes and hypertension appear to contribute to the development of erosive OLP lesions.
Area of Science:
- Immunology
- Oral Medicine
- Systemic Disease
Background:
- Oral lichen planus (OLP) is an inflammatory condition with uncertain etiology.
- Systemic factors like diabetes and hypertension are suspected contributors to OLP pathogenesis.
Purpose of the Study:
- To investigate the role of systemic factors (age, diabetes, hypertension) in the formation of subepithelial immune deposits in OLP.
- To determine the presence of circulating immune complexes (CIC) in OLP patients with and without systemic conditions.
Main Methods:
- Circulating immune complex (CIC) determination using polyethylene glycol precipitation.
- Analysis of sera from OLP patients, patients with diabetes mellitus, hypertension, leukoplakia, and healthy controls.
Main Results:
- CIC positivity was higher in OLP patients with diabetes compared to OLP patients without diabetes.
- CIC positivity was not found in control patients with diabetes.
- Hypertension, age, medication, dental foci, or metal framework did not show a clear association with CIC positivity in OLP.
Conclusions:
- CIC positivity in OLP may be a consequence of the condition itself.
- Diabetes and hypertension appear to contribute to the development of erosive OLP lesions.